NEW WORLD SYNDROME (OBESITY) GONE BY GUGGUL: A REVIEW
Background: Obesity is multi factorial disease, defined as a state of imbalance between calories ingested versus calories expended would lead to excessive or abnormal fat accumulation. Its prevalence is on continuous rise in all age groups of the developed as well as developing countries in the world and it can be described as the "New World syndrome". Chronic inflammation, oxidative stress and hyperlipedimia play significant role in pathogenesis of obesity. Aim & Objective: To assess effect of Guggul on New World Syndrome. Material & Methods: References of Guggul are search out in classical as well as contemporary science in new world syndrome. Observation: During survey of Ayurvedic literature it was observed that different herbs, metals, minerals are used for treatment of obesity as single drug as well as in compound formulations. Among herbs Guggul occupied significant position and effectively used for treatment of obesity. It is oleogum resin, obtained from Commiphora mukul originate in India, Bangladesh and Pakistan having anti hyperlipidemic, anti oxidant, anti inflammatory property which is opposite to causative agent of obesity. Besides this Guggul also act as drug delivery medium and help in transportation of anti obesity agent to target site and performing their action when used with other anti obesity drugs. Conclusion: Guggul is effective in New World syndrome and probably acting by different pharmacological properties.
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