Manjistha (Rubia cordifolia) - A helping herb in cure of acne
Acne is one of the most prevalent skin ailment affecting almost all teenagers, as it is chronic with frequent remission and exacerbations is often associated with negative psychological consequences, diminished self-esteem and social withdrawal. The Modern measures regarding the treatment of acne are more or less failure. Further it has some limitations, cost effective and many side effects. To overcome from all these, a good herbal approach should be reached. Manjistha (Rubia cordifolia) can be proven a best remedy to cure acne, due to its Varnya, Raktashodhak, Vishaghan, Rasayana, Krimighna properties. Certain research papers has also proven that it possess anti-inflammatory, antibacterial, antioxidant and ant- androgenic effects as these are important pharmacokinetic actions to break the pathogenesis of acne.
Patwardhan B, Warude N, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med. 2005; 2(4): 465-73.
Gupta AK, Tandon N, Sharma M.Quality standards of Indian Medicinal Plants, volume-3, Indian council of medicinal research New Delhi, 2005; 307.
Shrotri MK, Ghavane RC, Mukunda U. Indian Drugs 2005; 42(1): 20-23.
Gupta AK, Tandon N, Sharma M.Quality standards of Indian Medicinal Plants, volume-3, Indian council of medicinal research New Delhi,2005; 315
Sivarajan VV, Balachandran I. Ayurvedic Drugs and their Plant sources, Oxford & IBH Publishing Co. Pvt. Ltd., New Delhi, 1994; 292-93.
Bechtold T, Mussak R. Handbook of natural colorants. John Wiley & Sons Ltd., United Kingdom. 2009; 151-82.
Nadkarni KM. Indian Plants and Drugs. Asiatic Publishing House, New Delhi. 1998; 343-344.
Joshan RS, Nagarauk R, Anuradha P. Antibacterial properties of extracts of Indian medicinal plants: Syzygium alternifolium, Phyllanthus niruri Rubia cordifolia. Biomed. Pharmacol. J.. 2010; 3: 123-128.
Bhatt D, Kumar R, Joshi GC, Tewari LM. Indigenous uses of medicinal plants by the Vanraji tribes of Kumaun Himalaya. India. J. Med. Plants Res.. 2013; 7: 2747-2754.
Scheinfeld NS. Acne: a review of diagnosis and treatment. P & T. 2007; 32: 340-70.
Toyoda M, Morohashi M. Pathogenesis of acne. Med Electron Microsc. 2001; 34: 29–40.
Feldman S, Careccia RE, Barham KL, Hancox J. Diagnosis and treatment of acne. Am Fam Physician 2004; 69:2123–30.
Oprika C. Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases. Stockholm: Karolinska University. 2006.
Hamburger M, Hostettmann K. Bioactivity in plants: the link between phytochemistry and medicine. Phytochem. 1991; 30: 3864–74.
Sushruta. Commentary: Ayurvedatattva-Sandipika of Shastri Ambikadatt on Sushruta Samhita by Ambikadatta Shastri, Nidan Sthana chapter 13 verse no 38. Varanasi: Chaukhamba Surbharti Prakashan; 2012:372
Sharangdhar. Commentary: Jiwanprada of Srivastava Shailaja on Sharangdhar Samhita by Shailaja Srivastava, Purvakhanda, chapter 7, verse no 94 Varanasi: Chaukhamba Orientalia; 2011: 94.
Bhavamisra, Bhavaprakasha. Commentary: Vidyotini on Bhavaprakasha by Bhishgratna Pandit & Shri Bramha Shankar Mishra. Madhya khanda, chapter 61, verse no 31 Varanasi: Chaukhamba Sanskrit Bhawan;2012:587
Vagbhata, Astanga Hrdayam. Commentary: Sasilekha of Indu by Dr. Brahamanand Tripathi. Uttarsthana, chapter 31, verse no 5. Delhi: Chaukhamba Sanskrit Pratishthan;2009:1115.
Vagbhata, Ashtanga samgrah volume-III, English translation by murthy K.R.Srikantha, uttarasthan, chapter36, verse no 7. chaukhambha orientalia Varanasi;2005:813.
Agnivesa, charaka samhita. Commentary: Vidyotini by Kasinatha Sastri and Gorakha Natha Chaturvedi, sutrasthan volume-I, chapter 7, verse no 67. chaukhambha Bharati Academy Varanasi; 2011:259.
Agnivesa, charaka samhita. Commentary: Vidyotini by Kasinatha Sastri and Gorakha Natha Chaturvedi, sutrasthan volume-I, chapter-4, verse no 8. chaukhambha Bharati Academy Varanasi; 2011:78.
Agnivesa, charaka samhita. Commentary: Vidyotini by Kasinatha Sastri and Gorakha Natha Chaturvedi, sutrasthan volume-I, chapter-4, verse no 16. chaukhambha Bharati Academy Varanasi; 2011:83.
Agnivesa, charaka samhita. Commentary: Vidyotini by Kasinatha Sastri and Gorakha Natha Chaturvedi, sutrasthan volume-I, chapter-4, verse no 39. chaukhambha Bharati Academy Varanasi; 2011:92.
Susruta. Susruta samhita , English translation by murthy K.R. Srikantha, chikitsa sthan volume- II, chaukhambha orientalia Varanasi , edition 2005.
Bhavamisra, Bhavaprakasa,volume-I, commentary by Dr. Bulusu sitaram forword by Prof. K.C.Chuneker. Haritakyadi varga, verse no 189-191.chaukhamabha orientalia Varanasi;2006:173.
Kaiyadeva- Nighantuh, pathyapathya vibodhakah , edited and translated by prof. Priyavrata Sharma, Osadhi varga, verse no 1426-1427. chaukhambha orientalia Varanasi:264.
Vagbhata, Ashtanga samgrah with the sasilekha Sanskrit commentary by Indu Prologue in Sanskrit &English by prof. Jyotir mitra. Edited by Dr. Shivprasad Sharma. uttarasthan, chapter 37, verse no 19. Chowkhamba Sanskrit series office Varanasi ;2006:821.
Dravyaguna Vijnana, material medica vegetable drugs Part- II by Dr. Gyanendra pandey , krishavadas academy Varanasi , edition -1;2001:502-503.
The ayurvedic pharmacopoeia of India. Ministry of health and family welfare, Department of ISM&H, Govt. of India, New Delhi. 2001; Part-I & Vol-III: p.114.
Bhavamisra, Bhavaprakasa, Commentary Vidyotini by Bhisagratna Pandit and Bhahma Sankar Mishra ,volume-II, Kustharogadhikara, verse no 99-106. chaukhamabha Sanskrit Bhawan Varanasi,edition 11;2012:537.
Vrndamadhava or siddha yoga edited and translated by Dr. Premvati Tewari , , chapter 23, verse no 86-87. chaukhambha visvabharati Varanasi.
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 55, verse no 61-62. chaukhambha surbhirati prakashan Varanasi ; 2006:218
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 55, verse no 45. chaukhambha surbhirati prakashan Varanasi ; 2006:216
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 54, verse no 53-55. chaukhambha surbhirati prakashan Varanasi ; 2006:217.
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 54, verse no 56-57. chaukhambha surbhirati prakashan Varanasi ; 2006:217.
36. chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 54, verse no 58-60. chaukhambha surbhirati prakashan Varanasi ; 2006:217.
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 54, verse no 61-66. chaukhambha surbhirati prakashan Varanasi ; 2006:217.
chakrapani data, chakrudatta . padarthabodhini hindi commentary by vaidya Ravidatta shastri,chapter 54, verse no 42. chaukhambha surbhirati prakashan Varanasi ; 2006:216.
Sarangadhara, Sarangadhara samhita, uttara khanda, English translation by murthy K.R. Srikantha,Uttarkhand, chapter 11, verse no 9. chaukhambha orientalia Varanasi ; reprint 2010:427.
The ayurvedic pharmacopoeia of India. Ministry of health and family welfare, Department of ISM&H , Govt. of India, New Delhi. Part-I & Vol-III;2001:113.
Materia medica of Ayurveda, based on Ayurveda saukhyam of Todarananda by Vaidya Bhagwan dash, edition first 1980.
Gorle AM, Patil SS. Evaluation of antioxidant and antiacne property of Rubia cordifolia. Der Pharmacia Sinica. 2010; 1(3): 59-63.
Jain A, Bansal E, Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs, Phytomedicine .2003;10: 34–38.
Khan N, Karodi R, Siddiqui A, Thube S, Rub R, Development of anti-acne gel formulation of anthraquinones rich fraction from Rubia cordifolia (Rubiaceae), Int. J. Applied Res. Natl. Products. 2012; 4: 28-36.
Antarkar DS, Chinwalla T, Bhatt N.Anti-inflammatory activity of Rubia cordifolia Linn. In rats. Indian J Pharmac. 1983; 15: 185-188.
Antarkar SS, Chinwalla T, Bhatt N. Anti-inflammatory activity of Rubia cordifolia Linn. in rats, Indian J. Pharmacol.. 1983;15: 185-188.
Tripathi YB, Sharma M, Shukla S, Tripathi P, Thyagaraju K, Reddanna P.Rubia cordifolia inhibits potato lipoxygenase. Indian J. Exp. Biol..1995; 33: 109-112.
Basu S, Hazra B. Evaluation of nitric oxide scavenging activity, in vitro and ex vivo, of selected medicinal plants traditionally used in inflammatory diseases, Phytother. Res..2006; 20: 896-900.
Mischenko NP, Fedoreev SA, Bryukhanov VM, Zverev YF, Lampatov VV Azarova OV, Shkryl’Yu N, Chernoded GK. Chemical composition and pharmacological activity of anthraquinones from Rubia cordifolia cell culture. Pharm. Chem. J..2007;41:605-609.
Gorle AM, Patil SS. Evaluation of antioxidant and antiacne property of Rubia cordifolia. Der Pharmacia Sinica. 2010; 1 (3): 59-63.
Naidu KC, Lalam R, Bobbarala V. Antimicrobial agents from Rubia cordifolia and Glycyrrhiza glabra against phytopathogens of Gossypium.Int. J. Pharm. Tech. Res.. 2009;1: 1512-1518.
Singh R, Jain A, Panwar S, Gupta D, Khare SK. Antimicrobial activity of some naturaldyes. Dyes and Pigments. 2005;66: 99-102.
Sawhney R, Berry V, Kumar A. Inhibitory Activity of Rubia cordifolia plant extract against ESBL producing Urinary E. coli isolates. J. Pharmacy Res.. 2012; 5:1328-1330.
Basu S, Ghosh A, Hazra B. Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. And Lantana camara Linn.: isolation of Emodin and Physcion as active antibacterial agents. Phytother. Res.. 2005; 19:888-894.
Sharma BC. In vitro antibacterial activity of certain folk medicinal plants from Darjeeling Himalayas used to treat microbialinfections. J. Pharamcog. Phytochem.. 2013;2: 1-5.
Li X, Liu Z, Chen Y, Wang LJ, Zheng YN, Sun GZ, Ruan CC. Rubiacordone A: A New Anthraquinone Glycoside from the roots of Rubia cordifolia. Molecules. 2009; 14:566-572.
Mariselvam R, Ranjitsingh AJA, Nanthini AUR. Preparation and characterization of silver nanoparticles using Rubia cordifoli plant root extract and their microbial properties. Int J Adv Res. 2013;1: 56-61.
Tripathi YB, Sharma M, Manickam M. Rubiadin, a new antioxidant from Rubia cordifolia. Indian J Biochem Biophys. 1997; 34: 302-306.
Joharapurkar A A, Zambad S P, Wanjari M M, Umathe S N. In vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia linn. And its influence on ethanol-induced Immunosuppression. Indian Journal of Pharmacology. 2003; 35: 232-236.
Tripathi Y B, Sharma M.The interaction of Rubia cordifolia with iron redox status: a mechanistic as pectin free radical reactions. Phylo medicine,.Vol. 6(1), pp. 51-57.
Cai Yizhong, Sun Mei, Xing Jie, and Corke Harold. Antioxidant phenolic constituents in root of rheum officinale and rubia cordifolia: structure –radical scavenging activity relationships. J.Agric Chem.. 2004;52:7884-7890.
Tripathi Y B, Shukla S, Sharma V K. Antioxidant property of Rubia cordifolia extract and its comparison with vitamin E and parabenzoquinone. Phytotherapy research .1995;10:1002.
Gopal MG, Farahana B, Kulkarni KS. Effectiveness of Herbal Medication in treatment of Acne vulgaris- A pilot Study. The Indian Practioner. 2001;54(10): 723.
Oprika C. Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases. Stockholm: Karolinska. The Fellowship of Postgraduate Medicine, 1999.
Burkhart CG, Burkhart CN, Lehmann PF, Acne: a review of immunologic and microbiologic factors. Postgrad Med J. 1999;75:328–331.
Leyden, J.J. The evolving role of Propionibacterium acnes in acne. Semin. Cutan. Med. Surg.2001; 20:139–143.
Leyden, J.J., McGinley, K.J.,Vowels B. Propionibacterium acnes colonization in acne and non-acne. Dermatology.1998;196:55–58.
Boh E E, Role of reactive oxygen species in dermatologic diseases. Clin. Dermatol. 1996;14:343–352.
Cals-Grierson M.M., Ormerod A.D. Nitric oxide function in the skin. Nitric Oxide.2004; 10: 179–193.
Gougerot-Pocidalo, M. Revillard, J.. Oxidative stress, cytokines and lymphocyte activation. In: Fuchs, J. and Packer, L. (eds.) Oxidative Stress in Dermatology,. Marcel Dekker, New York .1993;187-205.
Trefzer U, Brockhaus M, Loetscher. The 55-kd tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation. J. Clin. Invest.. 1993; 92:462–470.
Wilmer J L, Burleson F G, Kayama K. Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical induced inflammation in mouse skin. J. Invest. Dermatol.. 1994; 102: 915–922.
Grewe M, Gyufko K, and Krutmanna J. Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. J. Invest. Dermatol.. 1995; 104: 3–6.
Kock A, Schwartz T, Kirnbauer R. et al. Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med.. 1990; 172 :1609–1614.
James, L.C., Moore, A.M., Wheeler, G.M. et al. Transforming growth factor alpha: in vivo release by normal human skin following UV irradiation and abrasion. Skin Pharmacol. 1991; 4: 61–64.
Pentland, Mahoney AP, M.G. Keratinocyte prostaglandin synthesis is enhanced by IL-1. J. Invest. Dermatol.. 1990; 94: 43–46.
Kanlayavattanakul M, Lourith N. Therapeutic agents and herbs in topical application for acne treatment. International Journal of Cosmetic Science. 2011; 33: 289–297.
Tripathi YB, Sharma M. Comparison of the antioxidant action of the alcoholic extract of Rubia cordifolia with rubiadin. Indian J. Biochem. Biophys.. 1998; 3: 313- 316.
Lodia S, Kansala L. Antioxidant activity of Rubia cordifolia against Lead toxicity. Int. J. Pharm. Sci. Res.. 2012; 3: 2224-2232.
Joharapurkar AA, Zambad SP, Wanjari MM, Umathe SN. In vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia Linn. and its influence on ethanol-induced immunosuppression. Indian J. Pharmacol.. 2003;35:232-236.
Tripathi YB, Sharma M, Manickam M. Rubiadin, a new antioxidant from Rubia cordifolia. Indian J. Biochem. Biophys.. 1997 ;34: 302-306.
Pandey S, Sharma M, Chaturvedi P, Tripathi YB. Protective effect of Rubia cordifolia on lipid peroxide formation in isolated rat liver homogenate. Indian J.Exp. Biol.. 1994; 32: 180-183.
Tripathi YB, Shukla S, Sharma M, Shukla VK. Antioxidant property of Rubia cordifolia extract and its comparison with vitamin E and parabenzoquinone. Phytother. Res.. 1995; 9: 440–443.
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