EFFECT OF PAPAYA LEAF JUICE ON PLATELET AND WBC COUNT IN DENGUE FEVER: A CASE REPORT
AbstractDengue fever caused by dengue viruses (dengue 1–4) having Aedes aegypti mosquito as their principal vector, causes symptoms such as sudden onset of fever, headache, retro-orbital pain and back pain along with severe myalgia due to which dengue fever is also known as “break-bone fever.” Laboratory findings include leukopenia, thrombocytopenia and in many cases, serum aminotransferase elevations. dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) may occur as a complication of dengue fever.A pilot study and a randomized controlled trial showed that administration of papaya leaf juice was beneficial in dengue patients in elevating the total white cell counts and platelet counts. Based on this report, a dengue patient with thrombocytopenia and leukopenia was treated in a tertiary Ayurveda hospital. The patient was administered papaya leaf juice in the dose of 25 ml twice daily along with conventional line of management for a period of eight days. There was remarkable improvement in the subjective symptoms and the white blood cell count and platelet count were restored to normalcy.
Peters CJ. Infections caused by arthropod and rodent. In: Harisson’s Principles of Internal Medicine. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et.al. 17thedi. USA: The McGraw-Hill Companies, Inc; 2008. p.1239.
Wikipedia, the free encyclopedia. Dengue fever. http://en.wikipedia.org/wiki/Dengue_fever (accessed 10 August 2013).
Hettige S. Salutary effects of Carica papaya leaf extract in dengue fever patients–a pilot study. Sri Lankan Family Physician 2008; 29:17-9.
Selisko B, Dutartre H, Guillemot JC. Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology 2006; 351(1):145–158.
Wang J, Xu J, Zhong J. Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patient with blood hyperviscosity syndrome. Zhing guo Zhong XI Yi Jie He Za Zhi 2004; 24:312-6.
Krishnamurti C, Kalayanarooj S, Cutting MA, Peat RA, Rothwell SW, Reid TJ, et.al. Mechanisms of hemorrhage in dengue without circulatory collapse. Am. J. Trop. Med. Hyg 2001; 65(6): 840–7.
Ahn Y, Bymes J, Harrington W, Cayer M, Smith D, Brunskill D, Pall M. The treatment of idiopathic thrombocytopenia with Vinblastine-loaded platelets. N Engl J Med 1998;298:1101-7.
Patil S, Shetty S, Bhide R, Narayanan S. Evaluation of Platelet Augmentation Activity of Carica papaya Leaf Aqueous Extract in Rats. Journal of Pharmacognosy and Phytochemistry 2013;1:57-60.
Tham CS, Chakravarthi S, Haleagrahara N, Alwis RD. Morphological study of bone marrow to assess the effects of lead acetate onhaemopoiesis and aplasia and the ameliorating role of Carica papaya extract. Exp Ther Med 2013;5:648-52.
Subenthiran S, Choon TC, Cheong KC, Thayan R, Teck MB, Muniandy PK et.al. Carica papaya leaves juice significantly accelerates the rate of increase in platelet count among patients with dengue fever and dengue haemorrhagic fever. Evidence-Based Complementary and Alternative Medicine 2013; Article ID 616737: 1-7. Available from: http://dx.doi.org/10.1155/2013/616737
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